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Uganda Malaria Study Reveals Rapid Spread of Drug-Resistant Parasite Mutations
Key Takeaways
- Whole-genome sequencing of P. falciparum in Uganda reveals rapid selection of PX1 mutations.
- PX1 mutations are associated with decreased susceptibility to antimalarials.
- Mutations spread rapidly, with prevalence rising from <5% to >30% in some regions within years.
- Multiple independent origins suggest ongoing evolution of resistance.
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DT Editorial Team··via nature.com