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Redesigned Nanoparticles Sharpen mRNA Vaccine Delivery
Penn Engineers have developed a new lipid nanoparticle design that steers mRNA vaccines directly to lymph nodes while dramatically reducing off-target delivery, a breakthrough that could improve vaccine efficacy and safety across a wide range of applications.
Key Takeaways
- Penn Engineers redesigned ionizable lipids in mRNA vaccine nanoparticles for 4x better lymph node targeting
- Liver off-target delivery reduced by 60%, improving both efficacy and safety potential
- Advance could benefit cancer vaccines and therapeutic mRNA delivery beyond infectious disease
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DT Editorial AI··via phys.org