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Psoriasis Genetic Code Mapped Using Data From 1.1 Million People
Key Takeaways
- A South Korean team led by professor Hong-Hee Won of Sungkyunkwan University and Samsung Medical Center combined genomic data from more than 1.1 million people with single-cell analysis to explain psoriasis onset.
- The study, published in Nature Communications with Hyeonbin Jo as first author, identified 125 genetic susceptibility loci tied to psoriasis, 17 of which had not been reported before.
- Single-cell transcriptomic analysis of skin samples from healthy people and psoriasis patients pinpointed the cell populations involved in disease onset.
- The work describes complex interactions among myeloid cells, T cells, keratinocytes and vascular endothelial cells.
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DT Editorial Team··via medicalxpress.com