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Approved Cancer Drug SAHA May Shield the Heart During Doxorubicin Chemotherapy
Key Takeaways
- Heidelberg researchers identified the molecular signaling pathway through which doxorubicin damages heart muscle, centered on topoisomerase IIβ and MEF2.
- SAHA, a drug already approved for certain cancers, attenuated harmful mechanisms in heart muscle cells in cell-based and animal studies.
- SAHA protected against chronic doxorubicin-induced cardiac dysfunction, fibrosis and transcriptional remodeling in vivo.
- Measurable changes in cardiac function appear in roughly one-quarter of doxorubicin-treated patients, raising long-term heart failure risk.
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DT Editorial Team··via medicalxpress.com