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KAIST's NUDGE Redirects Cell Fate Without Permanently Altering Genes
Key Takeaways
- KAIST researchers led by Professor Kwang-Hyun Cho developed NUDGE, a general-purpose computational framework for redirecting cell fate.
- The method relies on a single temporary intervention that harnesses a cell's existing gene regulatory dynamics instead of permanently locking genes on or off.
- Permanent control strategies can reduce cell plasticity and produce abnormal cell states that do not exist in nature.
- NUDGE operates in four stages: setting the target node, identifying minimal control targets, calculating relative stability, and analyzing the control mechanism.
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DT Editorial Team··via phys.org